Molecular modeling optimization of anticoagulant pyridine derivatives
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چکیده
منابع مشابه
Molecular docking, 3D-QSAR and structural optimization on imidazo-pyridine derivatives dually targeting AT1 and PPARγ
Telmisartan, a bifunctional agent of blood pressure lowering and glycemia reduction, was previously reported to antagonize angiotensin II type 1 (AT1) receptor and partially activate peroxisome proliferator-activated receptor γ (PPARγ) simultaneously. Through the modification to telmisartan, researchers designed and obtained imidazo-\pyridine derivatives with the IC50s of 0.49~94.1 nM against A...
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ژورنال
عنوان ژورنال: Journal of Molecular Graphics and Modelling
سال: 2008
ISSN: 1093-3263
DOI: 10.1016/j.jmgm.2008.01.006